Endocrine Abstracts

Introduction: Graves’ disease (GD) is an autoimmune thyroiditis frequently associated with development of Graves’ orbitopathy (GO). GD patients have lower vitamin D levels compared to the general population. Whether low vitamin D levels are associated with GO is still controversial. The aim of our study was to assess the vitamin D levels in patients with GO and the clinical outcome.Methods: This is a single-center observational study in an outp...

Introduction: Autoimmune thyroid disease (AITD) and abnormal carbohydrate metabolism are the commonest endocrine disorders in the general population. However, the effect that AITD may exert in β-cell secretion and insulin action in patients pre-diabetes has not been investigated before.Methods/design: One hundred and eighty-two patients (157 females) 46.5±14.2 years with pre-diabetes (impaired fasting glucose (IFG) or/and impaired glucose toler...

Introduction: The presence of antiphospholipid antibodies is associated pathogenically with thrombotic vascular events and resulting pregnancy complications. Studies support that antiphospholipid antibodies (aPL) impair female fertility by interfering with endometrial decidualization and implantation. This meta-analysis aims to determine the prevalence of aPL in women undergoing assisted reproductive techniques (ART) for in Vitro Fertilization and Embryo Transfer (IVF-ET)....

Introduction: Graves orbitopathy (GO) is an inflammatory condition of the orbital fat and muscles and affect 30-50% of patients with Graves’ disease. The first-line treatment of moderate to severe GO according to EUGOGO is intravenous glucocorticoids, but 20-30% of the cases appear to be corticosteroid resistant or refractory. Promising results have been described with Tocilizumab (TCZ) as a second-line moderate to severe GO treatment.Case presentat...

Introduction: The prevalence of lymph node metastasis from micropapillary thyroid carcinoma (mPTC) in different studies is up to 33%. Preoperative diagnosis of central lymph node (CLN) metastasis is essential for the surgical management of those patients. Prophylactic CLN dissection for patients with mPTC is controversial. Our study aimed to assess the prevalence and the risk factors of LMN metastasis in patients mPTC Methods: We retrospectively study th...

Introduction: Graves’ Orbitopathy (GO), the most common extrathyroidal manifestation of Graves’ disease (GD), usually presents bilateral disease. However, a minority of patients present with unilateral disease, the prevalence of which is between 4,5% and 14%. The aim of our study is to evaluate the specific demographic and clinical characteristics and potential differences between bilateral and unilateral GO, and the association with disease activity and severity.</p...

Introduction: Hyalinizing trabecular tumors are extremely rare and uncommon thyroid tumors, which were first described by Carney et al. Until now, their preoperative diagnosis based on cytological characteristics is not possible, because of the lack of specific features and molecular markers.Case presentation: We present a 38-year-old Caucasian female, non-smoker, with a disease-free medical history, with a right-sided clearly delimited large hy...

Introduction: Latent autoimmune diabetes of the adults (LADA) is a heterogeneous type of diabetes sharing clinical characteristics of type 2 DM and serum markers of pancreatic autoimmunity detected in type 1 DM. It accounts for 2-12% of all patients with diabetes. The aim of our study is to identify the association between LADA and other systemic or organ-specific autoimmune diseases.Materials and Methods: We conducted an observational study in the outpa...

Introduction: The development of malignancies in patients with Primary Hyperparathyroidism (PHP) occurs in the context of Multiple Endocrine Neoplasia (MEN) Syndrome. The association of PTH levels with cancer in patients with sporadic PHP has not been clarified. The aim of this study was to investigate whether PTH levels are related to the presence of thyroid cancer (TH) or other types of cancer in patients with PHP.Methods: We included patients with bio...

Introduction: Previous studies have shown that the G691S and S904S variants of RET proto-oncogene are associated with Multiple Endocrine Neoplasia (MEN) 2A syndrome and have a modifier effect on the age of onset. They are also associated with Papillary Thyroid Carcinoma and with Pheochromocytoma without Medullary Thyroid Carcinoma (MTC). Nevertheless, the influence of these polymorphisms on cases of sporadic MTC is still unclear. We present a patient with sporadic Med...